Pages. SELENITE, SODIUM : figure/table : figures and tables of selenium concentration over time (% of administered dose) . Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs." (1,2) [Abstract] Study Data Protocol Toxicity and Carcinogenicity Studies 3-Month Evaluation of the Toxicity (C04308) of Sodium Selenite (10102-18-8) in F344/N Rats Exposed via Dosed Water Sodium selenate is the inorganic compound with the formula Na 2 SeO 4, not to be confused with sodium selenite.It exists as the anhydrous salt, the heptahydrate, and the decahydrate. Sodium selenite 99%; CAS Number: 10102-18-8; EC Number: 233-267-9; Linear Formula: Na2SeO3; find Sigma-Aldrich-214485 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich . Lastly, it is essential to know that you should not use selenite damaged by water or saltwater, as the stone no longer has its beneficial properties. from inhalation exposure, sodium selenite to have extreme toxicity from oral exposure, and elemental selenium to have low toxicity from oral exposure. Toxic by ingestion, inhalation and skin absorption. Selenium dioxide is highly to moderately toxic, with oral LD50 values in rodents from 20 to 70 mg kg 1. 11. Signs and Symptoms of Sodium Selenite Exposure: Signs and symptoms of acute sodium selenite exposure include the following: garlic odor on breath, drooling, nasal irritation and burning sensation in nostrils, vomiting, hypotension . In one study, male and female Wistar rats were given dietary sodium selenite at concentrations of 0, 0.5, and 2.0 ppm in a semipurified high-protein diet for an entire lifetime (Tinsley et al., 1967; Harr et al., 1967). 10102-18-8): Listed for SARA Section 313 Chemicals: (Selenium Compounds- SARA 313) Toxic Substances subject to annual release reporting requirements listed at 40 CFR 372.65. (45.36 kg) Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). In extreme selenosis cirrhosis of the liver, pulmonary edema, or even death can occur. . Indeed, selenium was initially known as a toxic element in animal poisoning by selenium-rich plants . Formulating pig diets: Selenium toxicity, deficiency . Animal studies have reported that selenium supplementation, as sodium selenate, sodium selenite, and organic forms of selenium, results in a reduced incidence of several tumor types. More soluble compounds, for example, sodium selenite, are more toxic than the less soluble elemental selenium, selenium sulfide, or selenium disulfide. Sodium selenite is the inorganic compound with the formula Na2SeO3. Too much selenium -- more than 400 micrograms per day -- causes selenosis, a toxicity linked to bad breath, skin rashes and abnormal function of the nervous system. . Considerations and Risks While selenium supplements offer a wealth of potential benefits, you should only take them under medical supervision. A broad category of chemical actions with harmful or deadly effect on living organisms. It has a role as a nutraceutical. Sodium selenite is the most toxic compound when ingested orally. There was no evidence of teratogenicity in guinea pigs, mice, or rats. The National Institute of Health states that toxicity is very rare for sodium selenite. Summary of experiments to determine the toxicity of single doses of selenium in the form of sodium selenite administered orally to horseSy muleSj cattle, and swine Species and No. Sodium selenite is toxic in high concentrations. Based on the preceding review, the optimal form of Se for nutritional supplementation and cancer prevention would be expected to have distinctly low toxicity and to possess good . At high or toxic levels as much as 30 to 60% of selenium can be excreted via expired air , predominantly as dimethylselenide. The ingredient is even utilized as a selling point, which is very strange to say the least given its toxic properties. To formulate the chemicals, we use finest quality of compounds, procured from the most reputed and trusted vendors. The chronic toxic dose of selenium as Sodium Selenite for humans was estimated to be between 2.4 and 3 mg per day. Typical therapeutic dosage is in the range of 10-30 mg per day. In contrast, selenized yeast appears to have a higher selenium bioavailability than sodium selenite. The primary endpoint was safety, dose-limiting toxic effects and the MTD of sodium selenite. Live weight Dosage of Method of administration Selenium as sodium selenite per pound of body weight Result Sodium selenite Water Horse: 775 14.22 764 875 Pounds 1,185 970 The toxicity depends on the molecular form. In one study, sodium selenite was found to induce substantial DNA damage in human fibroblasts. However, elevated concentrations of Se in the body can also cause oxidative stress. Toxicity of Selenium was significantly higher in exponentially growing cells than in cells in the stationary phase . Author(s) Fairbrother, A. and J. Fowles. . Common Name: SODIUM SELENATE CAS Number: 13410-01- DOT Number: UN 2630 ----- HAZARD SUMMARY * Sodium Selenate can affect you when breathed in and may be absorbed through the skin. Vigasov D, et al. Dose limiting toxicities (DLTs) of the combination of sodium selenite plus abiraterone are defined as: Any Grade 3 non-hematologic toxicity (possibly, probably, or definitely-related adverse event) Any Grade 3 thrombocytopenia with bleeding Any Grade 4 thrombocytopenia persisting > 7 days Any Grade 4 neutropenia persisting > 7 days During pregnancy, a low Se status can increase the risk of oxidative stress. Sodium selenate and sodium selenite are used as supplements to poultry and livestock feed to promote growth and prevent selenium deficiency diseases. In contrast, selenocompounds, especially sodium selenite, can display pro-oxidant properties that may be toxic [19, 20]. Furthermore, it can damage the heart, liver, eyes, kidneys, and other organs, raising the risk of diabetes and even cancer. | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on TOXIC ACTIONS. Toxicity causes selenosis, with symptoms including fatigue, irritability, hair loss, garlic breath odor, mild nerve damage, white . Ionic Selenium Supplement 100ml | Contains Selenium in The Form of Sodium Selenate | Easy to Consume Selenium Liquid | Only Active Ingredients & Purified Water . Safety Data Sheet (SDS) for Sodium Selenite Revision Date: Jan 07, 2016 Version: A/1 4 / 15 P333+P313 If skin irritation or rash occurs: Get medical advice/attention. 61.15.1.3 Toxicity to Humans Accidental and Intentional Poisoning Apparently there is no record of human poisoning by sodium selenate. In cats, selenium toxicity can cause hair and coat loss, brittle nails, digestive disturbances, skin rashes, and nervous disorders. (1,3) . Selenite is non-toxic. * Sodium Selenite may cause mutations. . WGK 2. Not Reported : Toxicity Factor Datasets : Laboratory : Citation: Subchronic effects of sodium selenite and selenomethionine on several immune functions in mallards. The best . 1-48 of 132 results for "sodium selenite" RESULTS. WGK. Furthermore, saltwater will damage selenite even more, as salt is corrosive and highly abrasive on stones like selenite. The crystal structure of the anhydrous salt has been variously reported as tetragonal or monoclinic. Laboratory Findings When an overload of selenium (in its natural or artificial form) accumulates in the body, it can also cause damage to the heart, liver, eyes, kidneys, may contribute to the onset of diabetes and even be carcinogenic. Sodium selenite "may be toxic to blood, kidneys, liver, skin, central nervous system. Sodium selenite (Na 2 SeO 3) is a toxic inorganic salt that is highly soluble in water and insoluble in organic solvents. [8] As a result . The purpose of this study was to investigate the acute toxicity of sodium selenite in mice and rats after per os application to establish the relationship between a high toxic dose of sodium selenite and tissue alterations in rats. Unfortunately, there have not been identical studies done on dogs to see if that is also the case for them, so it's difficult to know if we can make assumptions based on this. SARA Section 313 (specific toxic chemical listings) 10102-18-8 Sodium selenite California Proposition 65 Prop 65 - Chemicals known to cause cancer Substance is not listed. Sodium selenite is a salt; a selenium compound that is water-soluble. Sodium selenite Revision Date 24-Dec-2021 Hazardous Polymerization Hazardous polymerization does not occur. The disodium salt of selenious acid. Contact China Manufactory Henan Tianfu Chemical Co.,ltd for the product Sodium selenite, 99%. The US Institute of Medicine set the adult Tolerable upper intake limits (UL) for selenium from all sources - food, drinking water, and dietary supplements - at 400 g/day in 2000. . TOX-38 Toxicity Studies of Sodium Selenate and Sodium Selenite (CASRNs 13410-01- and 10102-18-8) Administered in Drinking Water to F344/N Rats and B6C3F1Mice. This salt is a colourless solid. Mutagenesis 25: 155-162. That's because although the mineral is essential for normal cell function in all animals, selenium can be toxic in high doses. Both the acid and elemental form are well absorbed through the lungs and gastro-intestinal tract. In contrast, sodium selenite did not break DNA (lane 2) unless it was mixed with glutathione (lane 4), . 3, 8 selenium presents a nutritional conundrum because of its dual status as an essential but Two of 3 groups of castrated Landrace pigs, weighing 23.5 4.6 kg and anaesthetized with nitrous oxide and methoxyflurane received i.v. The heaviest concentration . CAMEO Chemicals When heated to decomposition, may emit toxic fumes of selenium and sodium oxide. Also, it is mainly used in the manufacture of colorless . "Sodium selenite may be toxic to blood, kidneys, liver, skin, central nervous system. Se toxicity lead to a condition called selenosis i.e., garlic odor of the breath, gastrointestinal disorders, hair loss, sloughing of nails, and neurological damage. Don't take my word for it, you can click on this link and read an actual MSDS Prop 65 - Developmental toxicity, female Substance is not listed. As sodium selenite, the chronic toxic dose for human beings was described as about 2.4 to 3 milligrams of selenium per day. Similarly, a human has a 50% chance of dying after consuming only 108 milligrams. It contains a disodium selenite. Mutagenesis. Arterial blood was taken before dosing and at 60 and 120 minutes when the pigs were killed. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE. Sodium selenite and sodium selenate have also been approved as feed additives at a maximum concentration of 0.5 mg selenium/kg feed (complete feed). In animals, the minimum lethal dose for intravenous administration of sodium selenite is between 1.5 and 3 mg/kg [22, 23]. Because selenium is an essential element, it is mainly used in feed additives and food industry. 6.1B - Non-combustible, acute toxic Cat. Abstract. The best protection is to 2 mg selenium/kg in 7.5 ml saline as, respectively, sodium selenite or dimethylselenide. Sodium selenite caused increases in NADP isocitric-dehydrogenase (NADP-ICDH . Soluble in water and more dense than water. Ingestion of about 1000 mg of sodium selenite caused a condition similar to arsenic poisoning with death in 5 hr (Moeschlin, 1965 ). [7] In 2000, the U.S. Institute of Medicine set the adult Tolerable upper intake levels (UL) for selenium from all sources - food, drinking water and dietary supplements - at 400 g/day. . Why is selenite toxic? Results and conclusion: MTD was defined as 10.2 mg/m(2), with a calculated median plasma half-life of 18.25 h. The maximum plasma concentration of selenium from a single dose of selenite increased . View Article The pentahydrate Na2SeO3(H2O)5 is the most common water-soluble selenium compound. Maruti Chemicals. The bioactivities and toxicities of inorganic sodium selenite, organic selenomethionine (SeMet), and Se-methylselenocysteine (SeMSC) have been extensively investigated. Meanwhile, the acute toxicity test results of bio-Se obtained from yeast were shown in Table 2. Chat now for more business. P362+364 Take off contaminated clothing and wash it before reuse. Toxicological information Acute Toxicity Product Information Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Sodium selenite LD50 = 7 mg/kg ( Rat ) Not listed Not . Handle with extreme caution. The secondary endpoint was primary response evaluation. : Sodium selenite: 100 lbs. Elimination (mostly in the urine) results in a biological half-life of around 1.2 days. Investigations on the role of base excision repair and non-homologous end-joining pathways in sodium selenite-induced toxicity and mutagenicity in Saccharomyces cerevisiae. The need for supplemental selenium in U.S. pig diets is largely dependent on the soil type in which the corn and soybeans are grown for inclusion in pig diets. Thirteen-week toxicity studies were conducted by administering the chemicals to groups of male and female F344/N rats and B6C3F1 . Based on our research, I would prefer that Se be 50 percent sodium selenite and 50 percent organically-derived (e.g., Sel-Plex). Prop 65 - Developmental toxicity Substance is not listed. * Contact can severely irritate and burn the skin and eyes with possible eye damage. 836-844. Statistical results of acute toxicity test for sodium selenite. sodium selenite 10102-18-8 >99 . The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs." (1,2) Sodium selenite significantly increases TBARS production (about 11.421.31pmol TBARS/mg protein compared to about 40.21 pmol TBARS/mg protein).The magnitude of increase was more than 3-fold at 5 mmol relative to the control. This method is a simple, low cost green synthesis alternative to chemical synthesis. Sodium selenite appears as a white colored crystalline solid. Abstract Selenium, an essential trace element, can also be toxic at higher levels of exposure. The anhydrous salt is used in the production of some glass. * Breathing Sodium Selenite can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath. These are white, water-soluble solids. SARA 302/304/311/312 extremely hazardous substances: Sodium selenite SARA 313 toxic chemical notification and release reporting: Sodium selenite CERCLA: Hazardous substances. However, some studies in rats suggested that Sodium Selenite was 2.94 times more toxic than an alternative form of Selenium called Selenium Yeast. * Breathing Sodium Selenite can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath. Both compounds have been found in chemical waste sites. In a Cochrane review of selenium and cancer prevention studies, compared with the lowest category of selenium intake, the highest intake category had a 31% lower cancer risk and 45% lower cancer mortality risk as well as a 33% lower risk of bladder cancer and, in men, 22% lower risk of prostate cancer [ 37 ]. Out of 5 stars 298 has been linked with the occurrence of liver and lung tumors mice. 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